Innovative Technological Development of Fertility Preservation Treatment Oriented to Improve Cancer Survivorship

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03830
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 56040:Obstetrics and gynecology-related
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: SUZUKI Nao 聖マリアンナ医科大学, 医学部, 教授 (90246356)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 小児・AYA世代がん / 妊孕性温存 / 卵巣組織凍結・移植 / 卵巣輸送 / 精巣組織凍結・移植 / 性腺毒性 / MRD / がん・生殖医療

Outline of Final Research Achievements

With an orientation toward technological innovation in fertility preservation (FP) treatment for cbildhood and AYA generation cancer patients, five research studies were conducted to develop technologies that can be deployed in Oncofertility medicine. 1.Research to examine MRD in the ovary and feasibility of ovarian transplantation in leukemia patients; 2.Research to establish an ovarian tissue cryopreservation center; 3.Research to develop optimal techniques for ovarian transplantation; 4.Development of new testicular tissue cryopreservation techniques; 5.Evaluation of gonadotoxicity of antitumor drugs (TKIs). The number of childhood and AYA generation cancer survivors who go on to acquire live births is on the rise, but since the target patients in this field are cancer patients, there is an urgent need for further innovation in the technologies used in FP treatment, which is the cornerstone of Oncofertility medicine, with an orientation toward "safety" and "efficacy".

Free Research Field

がん・生殖医療

Academic Significance and Societal Importance of the Research Achievements

がん・生殖医療の技術革新は依然課題が山積している。そこで本研究では、新しい技術や未だ臨床応用されていない技術の革新を志向して、がん・生殖医療に関わる新しい臨床技術開発を目的とした5つの研究を行った。本研究成果が、小児・AYA世代がん患者が将来希望をもってがんと闘うことができる、その「希望」に繋がると確信している。