2022 Fiscal Year Final Research Report

Development of multifunctional viscoelastic soft denture liners with controlled release ability of biologically active agent and photocatalyst function using nanocomposites

Research Project

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Project/Area Number	20H03880
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 57050:Prosthodontics-related
Research Institution	Nagasaki University
Principal Investigator	Murata Hiroshi 長崎大学, 医歯薬学総合研究科(歯学系), 教授 (40229993)
Co-Investigator(Kenkyū-buntansha)	小椎尾謙九州大学, 先導物質化学研究所, 准教授 (20346935) 筑波隆幸長崎大学, 医歯薬学総合研究科(歯学系), 教授 (30264055) 吉田和弘長崎大学, 医歯薬学総合研究科(歯学系), 助教 (70530418) 高瀬一馬長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (90736836)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	軟質リライン材 / 歯科補綴 / 粘弾性 / 光触媒 / 生理活性物質
Outline of Final Research Achievements	With the advent of a super-aging society, the number of patients with alveolar ridges that are unsuitable for denture prosthesis is increasing, and the number of patients complaining of pain caused by dentures is also increasing. As the effective treatment, soft denture liners have been widely applied. Soft Reline was covered by national insurance. However, an ideal soft denture liner has not yet been developed from the viewpoint of durability and stain resistance. The purpose of this research project is to develop a multifunctional viscoelastic soft denture liner with controlled release ability of biologically active agent and photocatalyst function using nanocomposites. In this study, especially the setting behavior and the viscoelastic behavior after setting were analyzed. We obtained knowledge to determine the composition of a light-polymerized soft denture liner with ideal setting behavior and viscoelastic properties.
Free Research Field	歯科補綴学
Academic Significance and Societal Importance of the Research Achievements	高齢者の多くは義歯を装着しているが、義歯を支える顎骨が低くなっているなど口腔は必ずしも義歯の装着に適した状態ではない方が多く存在する。そのため義歯を使用して食事を行った際、痛みや不都合を訴える方も多い。本研究ではとくに物性の観点から理想的な軟質リライン材（義歯に使用するクッション材）を開発するための必要な知見を得た。今後、高い耐久性など多くの機能をもつ軟質リライン材（義歯に使用するクッション材）を開発できれば、痛みの出にくい義歯治療の実現が期待できる。