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2023 Fiscal Year Final Research Report

A Novel Approach Targeting Metabolic Reprogramming for the Treatment of Destructive Temporomandibular Joint Cartilage Diseases

Research Project

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Project/Area Number 20H03896
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57070:Developmental dentistry-related
Research InstitutionOsaka University

Principal Investigator

INUBUSHI TOSHIHIRO  大阪大学, 歯学部附属病院, 講師 (30550941)

Co-Investigator(Kenkyū-buntansha) 古郷 幹彦  大阪大学, 大学院歯学研究科, 名誉教授 (20205371)
黒坂 寛  大阪大学, 大学院歯学研究科, 准教授 (20509369)
阿部 真土  大阪大学, 大学院歯学研究科, 講師 (40448105)
佐々木 淳一  大阪大学, 大学院歯学研究科, 講師 (50530490)
山城 隆  大阪大学, 大学院歯学研究科, 教授 (70294428)
宇佐美 悠  大阪大学, 大学院歯学研究科, 講師 (80444579)
Project Period (FY) 2020-04-01 – 2024-03-31
Keywordsヒアルロン酸 / Tmem2 / 変形性関節症
Outline of Final Research Achievements

In this study, it has been shown that Tmem2 is broadly expressed in knee cartilage, and that its expression increases in the superficial layer of articular cartilage in the early stages of osteoarthritis (OA). It has also been demonstrated that OA progresses significantly in Tmem2 knockout OA model mice. The accumulation of hyaluronic acid (HA) due to the loss of Tmem2 does not act protectively in articular cartilage, but rather may have a destructive effect. The results of this study suggest that the appropriate degradation and synthesis of HA by Tmem2 is important for the maintenance of homeostasis in articular cartilage, and that the disruption of HA regulatory mechanisms is associated with the onset and exacerbation of OA.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

本研究成果より、Tmem2が顎関節軟骨破壊性疾患の発症・進行機序解明ならびに新規治療法開発において新たな分子標的となることが期待でき、大きな意義を有している。また、HAの低分子化は膝関節OA、癌、難聴肺線維症や皮膚炎などの病態とも関わっており、本研究で得られた知見はこれらの疾患の病態解明や治療法開発へも応用可能であり、高い創造性を有しており、その学術的意義は非常に高い。

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Published: 2025-01-30  

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