Molecular epidemiologic studies for evaluating causal relationship between vitamin D and cancer risk based on large-scale cohort study.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H03950
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: National Cancer Center Japan
• Principal Investigator: Iwasaki Motoki 国立研究開発法人国立がん研究センター, がん対策研究所, 部長 (60392338)
• Co-Investigator(Kenkyū-buntansha): 口羽 文 神奈川県立保健福祉大学, ヘルスイノベーション研究科, 准教授 (40510699) ; 片桐 諒子 国立研究開発法人国立がん研究センター, がん対策研究所, 室長 (60813508)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 血中ビタミンD濃度 / がん罹患 / コホート研究 / メンデルのランダム化解析

Outline of Final Research Achievements

In order to utilize data from baseline and 5-year follow-up survey in the Japan Public Health Center-based Prospective (JPHC) Study, we proposed analytic framework for combining data from two case-cohorts established on the partially overlapped populations at two different surveys. We developed a new case-cohort including 5377 cancer cases based on the 5-year follow-up survey. Using data from the Japanese Consortium of Genetic Epidemiology and other studies in Japan, we conducted Mendelian randomization analyses and found no significant association between the genetically predicted plasma 25-hydroxyvitamin D concentration and total or colorectal cancer risk.

Free Research Field

がんの疫学

Academic Significance and Societal Importance of the Research Achievements

前向きコホート研究における血漿検体を用いた繰り返しデータの解析基盤は、国際的に見ても極めてユニークであり、この基盤を活用した研究の展開が期待される。未知・未観察の交絡因子の影響を制御するという観点において、メンデルのランダム化解析からのエビデンスは重要であり、ビタミンDとがんとの因果関係評価への貢献は大きい。