Experimental and epidemiological examination of the exercise effects on the communication between gut environment and skeletal muscle metabolism

2023 Fiscal Year Final Research Report

• Project/Area Number: 20H04080
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Kyoto Prefectural University
• Principal Investigator: Aoi Wataru 京都府立大学, 生命環境科学研究科, 准教授 (60405272)
• Co-Investigator(Kenkyū-buntansha): 内藤 裕二 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00305575) ; 小山 晃英 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40711362) ; 井上 亮 摂南大学, 農学部, 教授 (70443926)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 骨格筋 / エネルギー代謝 / 腸内細菌 / 臓器連関 / 血液中因子

Outline of Final Research Achievements

This study examined the relationship between gut environment and skeletal muscle metabolism in experimental animals, cultured cells, and humans. In recipient mice transplanted with gut microbiota from exercise-acclimated mice, energy metabolism in skeletal muscle was enhanced, indicating that deconjugation of bile acids by gut microbiota was involved in the activated metabolism. A cross-sectional study in middle-aged and elderly subjects also showed associations of physical activity and dietary habits with circulating bile acid composition. These results indicate that metabolic benefits of exercise involve communication between gut environment and skeletal muscle metabolism via changes in blood metabolites.

Free Research Field

スポーツ生理学

Academic Significance and Societal Importance of the Research Achievements

本研究により，腸内細菌叢の変化が，骨格筋のエネルギー代謝，ひいては全身の耐糖能や体組成を調整することが示された。また，運動習慣による代謝疾患の予防や体力の向上には，腸内細菌の働きによる血液中代謝物濃度の調整が関与することが示唆された。適切な運動習慣，食習慣は，健全な腸内環境ならびに骨格筋栄養素代謝を支え，両者のコミュニケーションが健康づくりに寄与すると考えられる。