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2022 Fiscal Year Final Research Report

Neural mechanisms underlying salty taste in the tongue and brain

Research Project

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Project/Area Number 20H04111
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Kengo Nomura  京都府立医科大学, 医学(系)研究科(研究院), 助教 (10734519)

Project Period (FY) 2020-04-01 – 2023-03-31
Keywords食塩 / 味覚 / 神経
Outline of Final Research Achievements

The Aim of the study was to elucidate the peripheral cellular mechanisms underlying attractive salty taste, which leads to excessive salt intake, and to clarify the neuronal circuit that processes this information and regulate behavior. Specifically, the study pursued four objectives: (I) identifying peripheral cells responsible for the perception of pleasant salty taste and understanding their signaling mechanisms, (II) developing optogenetic techniques to artificially induce salty taste, (III) identifying neurons responsive to sodium taste through photolabeling technology, and (IV) identifying taste-responsive neurons involved in regulating salt intake.

Free Research Field

生理学

Academic Significance and Societal Importance of the Research Achievements

本研究は、塩分過剰摂取の原因となる”好ましい”塩味が生じる仕組みの一端を解明することで、科学的根拠に基づく減塩方策の立案に通ずる。

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Published: 2024-01-30  

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