Investigations of the effects of supplementation of lipophilic vitamins aiming to improve prognosis of intracerebral hemorrhage

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H04126
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Kumamoto University
• Principal Investigator: KATSUKI Hiroshi 熊本大学, 大学院生命科学研究部(薬), 教授 (40240733)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 脳神経疾患 / 脳卒中 / 脂溶性ビタミン

Outline of Final Research Achievements

In this study, daily oral administration of vitamin A or its derivative was found to produce beneficial effects with respect to motor function recovery and neuroprotection in a mouse model of intracerebral hemorrhage. Additionally, signaling mechanisms involved in these actions of vitamin A derivatives were analyzed in rat organotypic brain slice cultures. A vitamin K homolog was also found to alleviate motor dysfunction associated with intracerebral hemorrhage, with a pharmacological profile distinct from vitamin A derivatives in terms of brain tissue protection.

Free Research Field

神経薬理学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、十分な治療法の確立されていない脳出血（出血性脳卒中）に対して脂溶性ビタミン類の強化補給が有効である可能性を提示しており、脳病理の制御に立脚した新たな栄養学的管理法の提案につながるものである。脳出血を適応疾患とする医薬品の開発は世界的に見ても遅々として進んでいないが、本研究の成果を契機として脳卒中後のケアにおける積極的な栄養管理・強化補給の概念が確立されれば、医薬品に依存しない新たな医療介入法を提供できる。