Strategy for Prevention of Chronic Kidney Disease (CKD) Severity: Analysis of Phosphorus Time Nutrition

2022 Fiscal Year Final Research Report

• Project/Area Number: 20H04127
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: The University of Shiga Prefecture
• Principal Investigator: Sawako Tatsumi 滋賀県立大学, 人間文化学部, 教授 (80420545)
• Co-Investigator(Kenkyū-buntansha): 桑原 頌治 滋賀県立大学, 人間文化学部, 准教授 (70645209)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 時間栄養 / リン / Nampt

Outline of Final Research Achievements

In this study, "Elucidation of Circadian Rhythm Formation Mechanism of Plasma Phosphate Concentration and Phosphate Chrono-nutrition Therapy" was investigated to prevent the severity of chronic kidney disease (CKD). Liver-specific Nampt-deficient (LNKO) mice showed abnormal circadian rhythm of blood phosphorus concentration. Furthermore, LNKO was found to cause severe CKD. In wild-type CKD mice, the circadian rhythm of plasma phosphate concentration was improved, and the progression of hyperphosphatemia and CKD was suppressed by adjusting the timing of the diet and the diet containing Nampt activating factors. These results suggest that promotion of Nampt/NAD system activation, meal timing and diet content are targets for establishing phosphate- Chrono-nutritional therapy for CKD patients.

Free Research Field

時間栄養学　腎臓病学

Academic Significance and Societal Importance of the Research Achievements

本研究はマウスで実施したものであるが、血中リン濃度の日内リズム調節因子(Nampt活性化因子)の複数の候補を見出したことで、微量な血液や尿により、Nampt活性化因子を測定することで、慢性腎臓病の進展予測ができると考えられる。さらに透析を導入されている患者では、定期的に採血や蓄尿を実施しているため、地域の透析病院などと連携することができれば、時間栄養療法だけではなく、Nampt活性化因子をターゲットとした治療薬の開発や、先制医療にもつながる基盤研究となるため、学術的創造性が高いと考える。