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2022 Fiscal Year Final Research Report

Studies of piezoelectricity and ferroelectricity of biological tissues by acoustic-induced electromagnetic method and development for medical applications

Research Project

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Project/Area Number 20H04500
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90110:Biomedical engineering-related
Research InstitutionTokyo University of Agriculture and Technology

Principal Investigator

Ikushima Kenji  東京農工大学, 工学(系)研究科(研究院), 教授 (20334302)

Project Period (FY) 2020-04-01 – 2023-03-31
Keywords生体医工学 / 超音波 / 音響誘起電磁法 / 圧電効果 / コラーゲン / 線維化
Outline of Final Research Achievements

In this study, the piezoelectricity of biological tissues was clarified using the acoustically induced electromagnetic (ASEM) method, and its potential for medical diagnosis was pursued. The main results are as follows: (1) a large anisotropy of acoustic-induced polarization in biological fibrous tissues (bone, tendon, muscle tissue, etc.) was confirmed, suggesting that it is associated with symmetry of the fibrous structure; (2) a trend of decreased acoustic-induced polarization was found in rat osteoporosis models, indicating its potential for osteoporosis diagnosis; (3) human measurements have become possible and successful imaging of acoustic-induced polarization in bones, tendons, and other tissues in the body has been achieved.

Free Research Field

応用物理学

Academic Significance and Societal Importance of the Research Achievements

本研究により、生体線維組織において超音波によって誘起される電気分極(音響誘起分極)は、等方的に生じるわけではなく、コラーゲン等の線維状タンパク質の配列や構造に起因していることが示唆された。さらに、ラット骨粗鬆症モデルにおいては分極が小さくなることが明らかにされた。これらの結果から、湿潤または生きた生体組織において構造由来の圧電分極が生じることが確認され、その分極の大きさや異方性が運動器官組織の健全性を評価する指標になることが見込まれる。一方、ヒト体内の骨や腱からの分極を画像化することに成功し、基礎研究から臨床研究へ進む大きな一歩を踏み出した。

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Published: 2024-01-30  

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