2022 Fiscal Year Final Research Report

Development of novel cancer therapy based on promotion of tumor infiltrating lymphocyte by the immunomodulation with ultrasound technology

Research Project

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Project/Area Number	20H04519
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 90110:Biomedical engineering-related
Research Institution	Teikyo University
Principal Investigator	Suzuki Ryo 帝京大学, 薬学部, 教授 (90384784)
Co-Investigator(Kenkyū-buntansha)	工藤信樹北海道大学, 情報科学研究院, 准教授 (30271638) 岡田欣晃大阪大学, 大学院薬学研究科, 准教授 (50444500) 小山正平大阪大学, 大学院医学系研究科, 特任准教授 (80767559)
Project Period (FY)	2020-04-01 – 2023-03-31
Keywords	超音波 / マイクロバブル / 養子免疫療法 / 腫瘍微小環境 / イムノモジュレーション
Outline of Final Research Achievements	Adoptive immunotherapy such as CAR-T therapy has achieved good clinical results in hematologic cancers. However, the efficacy of adoptive immunotherapy is limited in solid tumors with immunosuppressive tumor microenvironment (TME). Therefore, it is necessary to change the TME to activate antitumor immunity. In this study, we attempted to change the TME via induction of tumor tissue damage by the mechanical action of microbubble (MB) under ultrasound (US) irradiation and investigated the possibility of enhancing the antitumor effect in adoptive immunotherapy combined with the treatment of MB and US irradiation. The antitumor effect was enhanced when adoptive immunotherapy was combined with MB and US irradiation. This result suggests that MB and US irradiation are promising a combination therapy that can enhance the efficacy of adoptive immunotherapy for solid tumors by inducing immunological TME conversion (immunomodulation).
Free Research Field	超音波医学
Academic Significance and Societal Importance of the Research Achievements	本研究成果は、養子免疫療法で課題となっていた固形がんに対する治療効果を得るための画期的な併用療法を提案するものである。養子免疫療法として注目されているCAR-T療法は、血液がんに対して著効を示していたことから、マイクロバブルと超音波照射の併用が可能となれば、様々な難治性固形がんに対する革新的な治療法になるものと期待される。そのため、本研究成果は、学術的にも社会的にも大きな意義のある基礎研究結果である。