2022 Fiscal Year Final Research Report
Elucidation of cerebral circulation by the use of polymeric MRI contrast agents
| Project/Area Number |
20H04536
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
白石 貢一 東京慈恵会医科大学, 医学部, 准教授 (40426284)
小松 鉄平 東京慈恵会医科大学, 医学部, 講師 (60723856)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Glymphatic system / アルツハイマー病 / 高分子MRI造影剤 / 低分子MRI造影剤 / Gd蓄積 / MRI / 脳循環 |
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| Outline of Final Research Achievements |
This study revealed by the used of MRI and MRI-contrast agents that macromolecules transferred from the blood into the cerebrospinal fluid, and that this transfer was site-specific among several cerebrospinal-fluid-containing sites in the brain.
This transfer, in other words, enhancement of the blood-cerebrospinal fluid barrier’s (BCSFB’s) permeability was observed to be enhanced by young ages of mouse and by mannitol pre-injection. Mannitol is known to enhance blood brain barrrier’s (BBB’s) permeability, but the enhancement degree was found to be much higher for BCSFB than for BBB.
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| Free Research Field |
ドラッグデリバリーシステム
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| Academic Significance and Societal Importance of the Research Achievements |
従来測定の対象になっていなかった血液脳脊髄液関門の高分子透過性という、基礎的な生体挙動をMRIの手法でその透過部位も含めて明らかにすることに成功した学術的価値は高いと考えられる。また、その透過性は様々な要因によって亢進し得ることから、脳神経疾患の病理に新しい解明の糸口を与える可能性がある。
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