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2021 Fiscal Year Annual Research Report

尿中フタル酸代謝物と喘息及び酸化ストレスとの関連

Research Project

Project/Area Number 20J10766
Research InstitutionHokkaido University

Principal Investigator

KETEMA RAHEL MESFIN  北海道大学, 保健科学院, 特別研究員(DC2)

Project Period (FY) 2020-04-24 – 2022-03-31
KeywordsBiomonitoring / Phthalate esters / School children / Allergies / Oxidative stress markers
Outline of Annual Research Achievements

Urine was collected from 7-year-old children participating in the Hokkaido birth cohort, and 10 metabolites of 4 phthalate compounds were measured by UPLC-MS/MS. Levels of 3 oxidative stress markers (8-OHdG, HEL, HNE)) were measured by ELISA kits. ISAAC questionnaire completed by parents of the child used to define wheeze, rhino conjunctivitis, and eczema.
All metabolites were detected in > 96% of samples. Highest detection was in MECPP, MnBP, and MEHHP with median 37.4 ng/mL, 36.8 ng/mL, and 25.8 ng/mL, respectively. No exposure change was observed in these phthalate metabolites from 2012 to 2017. The Japan phthalate ester regulation revised in 2010 in toys and food containers related to children could not alter the phthalates exposure change. Individual phthalate metabolites, MECPP (OR = 1.41) and cx-MINP (OR = 1.40) increased the risk of wheeze. In a mixed exposure analysis, the Weighted Quantile Sum index showed significant association (OR = 1.46) with wheeze and (OR = 1.40) eczema. The Bayesian Kernel Machine Regression model, DINP metabolites showed the highest group posterior inclusion probability (PIP). Among DINP metabolites, MINP in wheeze, cx-MINP in rhino-conjunctivitis and OH-MINP in eczema showed the highest conditional PIPs. The overall metabolites mixture effect was associated with eczema. On the contrary, no mediation of oxidative stress was observed in the association between phthalates and symptoms, which may be due to low oxidative stress. Participants in this study were only 7 years old, demonstrating the importance of continuing the study in the future.

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

  • Research Products

    (5 results)

All 2022 2021

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Phthalates mixture on allergies and oxidative stress biomarkers among children: The Hokkaido study.2022

    • Author(s)
      Rahel Mesfin Ketema, Yu Ait Bamai, Takeshi Saito, Reiko Kishi, Atsuko Ikeda-Araki.
    • Journal Title

      Environmental International

      Volume: 160 Pages: 107083~ 107083

    • DOI

      10.1016/j.envint.2022.107083.

    • Open Access / Int'l Joint Research
  • [Journal Article] Secular trends of urinary phthalate metabolites in 7-year-old children and association with building characteristics: Hokkaido study on environment and children’s health.2021

    • Author(s)
      Rahel Mesfin Ketema, Yu Ait Bamai, Atsuko Ikeda Araki, Takeshi Saito, Reiko Kishi.
    • Journal Title

      International Journal of Hygiene and Environmental Health

      Volume: 234 Pages: 113724~ 113724

    • DOI

      10.1016/j.ijheh.2021.113724.

    • Int'l Joint Research
  • [Journal Article] Hokkaido birth cohort study on environment and children’s health: cohort profile 2021.2021

    • Author(s)
      Reiko Kishi, Atsuko Ikeda-Araki, Chihiro Miyashita, Sachiko Itoh, Sumitaka Kobayashi, Yu Ait Bamai, Keiko Yamazaki, Naomi Tamura, Machiko Minatoya, Rahel Mesfin Ketema, Kritika Poudel, Ryu Miura, Hideyuki Masuda, Mariko Itoh, Takeshi Yamaguchi, Hisanori Fukunaga, Kumiko Ito, Houman Goudarzi.
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 26(1):59 Pages: -

    • DOI

      10.1186/s12199-021-00980-y.

    • Int'l Joint Research
  • [Presentation] Association of phthalates exposure and oxidative stress biomarkers with wheeze, rhino-conjunctivitis and eczema in children.2021

    • Author(s)
      Rahel Mesfin Ketema, Yu Ait Bamai, Atsuko Ikeda Araki, Takeshi Saito, Reiko Kishi.
    • Organizer
      International Society of Exposure Science.
    • Int'l Joint Research
  • [Presentation] Mixture effect of phthalate metabolites in children’s wheeze, rhino-conjunctivitis and eczema: The Hokkaido study.2021

    • Author(s)
      Rahel Mesfin Ketema, Yu Ait Bamai, Takeshi Saito, Reiko Kishi, and Atsuko Ikeda-Araki.
    • Organizer
      The Fifth FHS International Conference.
    • Int'l Joint Research

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Published: 2022-12-28  

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