2022 Fiscal Year Final Research Report
Renal function and chronic renal failure mechanisms based on biomechanical modeling
| Project/Area Number |
20K04281
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 19010:Fluid engineering-related
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
菅原 路子 千葉大学, 大学院工学研究院, 准教授 (30323041)
中田 敏是 千葉大学, 大学院工学研究院, 准教授 (80793190)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | バイオメカニクス / レオロジー / 微小循環 / 腎臓 / 計算機シミュレーション |
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| Outline of Final Research Achievements |
Computer simulation of flow in the kidney was performed. First, a renal vascular network geometry was constructed using the vascular bifurcation style (symmetric or asymmetric) and the number of vascular branches. Blood flow calculations using this model revealed that in physiological vascular network structures, flow and pressure are spatially distributed due to asymmetric vascular bifurcations. It was also found that blood cells and blood flow in the vascular network are unevenly distributed in space due to the rotational motion patterns of blood cells and the asymmetry of the vascular branches. Such flow distribution may be related to kidney function and local lesions through the uneven distribution of mass transport and mechanical quantities.
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| Free Research Field |
バイオメカニクス
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| Academic Significance and Societal Importance of the Research Achievements |
血管網の非対称な構造ならびに赤血球の回転運動が腎臓内の流量や圧力の時空間的な変動に与える影響の一端を明らかにした．これは，腎臓の生理的および病的な振る舞いに対して，流れの力学が重要な役割を果たすことを示唆する結果であり，腎機能の深い理解とそれに基づくCKDの発症・進展機序の解明において，流れのバイオメカニクス研究の重要性を示すものと考えられる．本研究は，簡易で低コストな高機能診断や発病予測などの高度な医療技術の創造に繋がると期待される．
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