2023 Fiscal Year Final Research Report
Development and effects of a high-frequency, high-voltage burst pulse generating circuit superimposed with effective low-frequency wave in cancer treatment
| Project/Area Number |
20K04436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 21010:Power engineering-related
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | パルス電界 / バーストパルス / がん細胞 / アポトーシス / ネクローシス / 細部膜 / 絶縁破壊 / 活性種 |
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| Outline of Final Research Achievements |
We investigated replacing the gap switch of the burst pulse generator to a solid-state switch to enhance the effect on cells, and the effect of superimposing low frequency on high frequency. As a result, it became possible to replace the gap switch of the secondary switch with the solid-state switch, and a foundation was established for superimposing any low frequency on high frequency. Regarding the effect of superimposing low frequency on high frequency, we made stabilizing the burst pulse output of 10 trains and halved the superimposed frequency. As a result, the rate of cell death was clearly higher with a 10 trains waveform compared to a 5 trains waveform, even though the total number of pulses applied was the same. This is thought to be the effect of increasing the number of burst pulses applied at once, which lowered the superimposed frequency and increased the time for continuous pulse application.
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| Free Research Field |
パルスパワー
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| Academic Significance and Societal Importance of the Research Achievements |
アポトーシス作用でがんが治癒するというのは元々体に備わっている機能でがんが治癒するということであり，副作用の少ないがん治療が期待できる。がんは日本人の死亡原因１位で，人口10万に250人の割合で，がんで死亡している。２位の心疾患の２倍の死亡率である。がんを外科治療より簡単に，放射線，化学治療のように副作用もなく安全，簡便に行えると，市民生活にこの上ない安心感を与えることが可能になる。しかも粒子線治療のような巨大で高価な装置でなく，コンパクトで安価な装置を作ることが可能となるので，高度先進医療施設だけでなく，中小の病院でも非外科治療導入が可能になり，市民が容易に安価で治療を受けられるようになる。
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