Research on brain fluorescence imaging without craniotomy light through scattering medium

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K04517
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 21030:Measurement engineering-related
• Research Institution: Seikei University (2022-2023); University of Miyazaki (2020-2021)
• Principal Investigator: Nakano Kazuya 成蹊大学, 理工学部, 准教授 (80713833)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 位相回復 / スペックル / 散乱光

Outline of Final Research Achievements

In this study, we conducted a basic research to reconstruct the image of an object before passing through the scattering medium from the light scattered by the scattering medium. Experiments were conducted using scattering media ranging from a diffuser to a phantom. Several imaging systems for the image reconstruction were tested. In addition, we focused on the optical memory effect, which is used as a reconstruction principle, and constructed an optical system to investigate it. The image reconstruction was successful under certain conditions, and the optical memory effect was also confirmed.

Free Research Field

生体医用光学，光情報処理

Academic Significance and Societal Importance of the Research Achievements

生体組織といった散乱媒質中の物体を光によりイメージングしようとすると，光が散乱や吸収されることから，媒質の厚さや散乱係数などにより媒質中の物体を確認することが困難になる．本研究ではそのような散乱媒質を通過した光から物体像を再構成及びその原理となっているoptical memory effectに対する基礎的な研究を実施している．本成果が散乱媒質中の物体を観察するアプローチの１つになるものと考えている．