Development of integrated circuits constructed from DNA analogues and application to parallel computing using DNA

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K04603
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 21060:Electron device and electronic equipment-related
• Research Institution: The University of Kitakyushu
• Principal Investigator: ISODA TAKAAKI 北九州市立大学, 国際環境工学部, 教授 (70284544)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: MEMS / DNA / 抗体 / 素子 / 集積

Outline of Final Research Achievements

The goal of this research is to make an integrated electrode with 16-bit (approximately 6.6×10^4) addresses of DNA with different base sequences function as a high-precision parallel computing element. For that purpose, it is necessary to establish elemental technology that allows artificially designed DNA analogues to operate as operators in electronic circuits with good reproducibility. Therefore, we fabricated an integrated electrode pair with 4.5-bit (approximately 25) addresses for integrating DNA analogues on a resin substrate, and developed a serial measuring device that can automatically measure signals by continuously switching the signals of this electrode group. developed. Next, in order to detect the base sequence as an electrical signal, we established a detection technique by accumulating antibody molecules, which have the same complex-forming function as DNA, on an electrode.

Free Research Field

生物センサ工学

Academic Significance and Societal Importance of the Research Achievements

現在のCPUの演算は、1つの計算を高速に無限回数繰り返して解を求める行うシリアル方式である。これに対し一度に無秩序の組合せを計算し、その中から解を特定するパラレル方式がある。本研究はこれを無作為に結合したDNAから、正解の塩基配列を持つDNAを検出する生物デバイスに置き換え、これを1チップ化することを目標としている。生物は膨大なDNA塩基配列から必要箇所を正確にコピーし、遺伝情報を伝達している。このような生物の仕組みを模倣しつつ、DNAよりはるかに多彩な認識能を持つ抗体分子で集積回路を構築できれば、塩基配列を再現よく検出する方法に道が開け、DNA並列計算素子実現の大きな一歩となる。