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2022 Fiscal Year Final Research Report

Surface defects and morphology control of two-dimensional nanostructured titanium dioxide and its application to anti-infective medical materials

Research Project

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Project/Area Number 20K05123
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 26030:Composite materials and interfaces-related
Research InstitutionJapan Fine Ceramics Center

Principal Investigator

HASHIMOTO Masami  一般財団法人ファインセラミックスセンター, その他部局等, 上級研究員 (20450851)

Co-Investigator(Kenkyū-buntansha) 金高 弘恭  東北大学, 歯学研究科, 教授 (50292222)
Project Period (FY) 2020-04-01 – 2023-03-31
Keywordsナノシート / 酸化チタン / 細胞増殖性
Outline of Final Research Achievements

Biocompatibility and anti-infectivity are required for dental implants and catheters, and it is extremely difficult to improve these conflicting functions simultaneously. By forming titanium dioxide nanosheets, it is expected that not only the above conflicting functions can be controlled, but also the surfaces of components with various materials and shapes can be coated. We coated nanosheets on Ti implant surfaces at room temperature and explored their potential as a medical material. As a result, titanium dioxide nanosheets were successfully coated on medical components, and it was confirmed that they showed good cell proliferation properties. On the other hand, as for the antimicrobial property, first of all, hydroxyl radicals could not be confirmed from the results of electron spin resonance method, and antimicrobial property could not be confirmed in the antimicrobial property test using E. coli.

Free Research Field

材料工学

Academic Significance and Societal Importance of the Research Achievements

抗菌性と生体活性能を併せ持つ酸化チタンナノシートは、室温下で柔軟性のある基材にもコーティング可能なため、感染が問題になっているインプラントだけでなく、カテーテル等の経皮端子や手術室での噴霧による抗菌性環境の実現等が可能であると考えられる。

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Published: 2024-01-30  

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