2022 Fiscal Year Final Research Report
Surface defects and morphology control of two-dimensional nanostructured titanium dioxide and its application to anti-infective medical materials
Project/Area Number |
20K05123
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 26030:Composite materials and interfaces-related
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Research Institution | Japan Fine Ceramics Center |
Principal Investigator |
HASHIMOTO Masami 一般財団法人ファインセラミックスセンター, その他部局等, 上級研究員 (20450851)
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Co-Investigator(Kenkyū-buntansha) |
金高 弘恭 東北大学, 歯学研究科, 教授 (50292222)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | ナノシート / 酸化チタン / 細胞増殖性 |
Outline of Final Research Achievements |
Biocompatibility and anti-infectivity are required for dental implants and catheters, and it is extremely difficult to improve these conflicting functions simultaneously. By forming titanium dioxide nanosheets, it is expected that not only the above conflicting functions can be controlled, but also the surfaces of components with various materials and shapes can be coated. We coated nanosheets on Ti implant surfaces at room temperature and explored their potential as a medical material. As a result, titanium dioxide nanosheets were successfully coated on medical components, and it was confirmed that they showed good cell proliferation properties. On the other hand, as for the antimicrobial property, first of all, hydroxyl radicals could not be confirmed from the results of electron spin resonance method, and antimicrobial property could not be confirmed in the antimicrobial property test using E. coli.
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Free Research Field |
材料工学
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Academic Significance and Societal Importance of the Research Achievements |
抗菌性と生体活性能を併せ持つ酸化チタンナノシートは、室温下で柔軟性のある基材にもコーティング可能なため、感染が問題になっているインプラントだけでなく、カテーテル等の経皮端子や手術室での噴霧による抗菌性環境の実現等が可能であると考えられる。
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