Development of supercritical fluid extraction method to solve various problems of entrainer

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K05192
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 27010:Transport phenomena and unit operations-related
• Research Institution: Nagoya University
• Principal Investigator: Kanda Hideki 名古屋大学, 工学研究科, 助教 (90371624)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 液化ジメチルエーテル / 超臨界二酸化炭素 / 抽出 / 溶媒

Outline of Final Research Achievements

Extraction of neutral lipids from soybean lipids was attempted using a DME/SC-CO2 mixture system, and the effects of DME in promoting extraction and reducing operating pressure were confirmed. In addition, the extraction of curcumin from turmeric and the extraction of lipids from microalgae were also improved by the DME/SC-CO2 mixture system. In an attempt to apply the extraction properties of liquefied DME, liposomes were successfully produced from phospholipids using liquefied DME as a medium, and this is currently being expanded to a DME/SC-CO2 mixture system. We have also succeeded in producing scaffolds for DNA extraction and removal from ostrich carotid artery, porcine brain, porcine cartilage, and porcine aorta using liquefied DME and DNase in combination, achieving results beyond our initial plans.

Free Research Field

マテリアル工学

Academic Significance and Societal Importance of the Research Achievements

代表的なグリーン溶媒である超臨界二酸化炭素（SC-CO2）に液体の助溶媒（エントレーナー）を混合して、SC-CO2による抽出量を増大させる手法は古くから研究されているが、抽出物や残渣にエントレーナーが残留する、作業環境中の空気が汚染される問題がある。一方で近年グリーン溶媒として注目されている液化ジメチルエーテル(DME)は沸点が－24.8℃で残留の懸念が無く毒性が僅かで安価で微極性という多くの利点がある。このDMEの溶媒としての特性を明らかにするとともに、DMEをSC-CO2のエントレーナーとして用いる手法を開発すれば、従来のグリーン溶媒抽出の環境調和性や操作条件の改善が期待できる。