2020 Fiscal Year Research-status Report
Externally Triggered Nanomachine for Breast Cancer Theranostics
| Project/Area Number |
20K05260
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| Research Institution | Saitama University |
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Principal Investigator |
ルカノフ アレクサンダー 埼玉大学, 理工学研究科, 准教授 (40751566)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Nanozyme / Carbon nanodots / Photosensitization |
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| Outline of Annual Research Achievements |
The ability of histidine-contained carbon nanodots to act as effective nanozyme through activation with visible light was demonstrated. The usage of visible electromagnetic irradiation (in the range 400-500 nm) was particularly desirable, because it is not dangerous as comparison with the ultraviolet light. The successful incorporation of pyrrolic nitrogen doping (from imidazole group) into the aromatic domains enables to the nanozyme to achieve enhanced photosensitization reaction of singlet oxygen production. The essence of developed strategy was based on the aspect that pyrrolic nitrogen is identified as the major site in the nanozyme for adsorption of oxygen. It helped to shorten the distance between C-dots surface and oxygen, which was a crucial step.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
I changed the job from Saitama University to National Institute of Technology, Gunma College. At my new working place I am creating a new laboratory and the process is difficult and time consuming. Due to this reason the planned experiments for March, April and May are delayed for June, July and August.
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| Strategy for Future Research Activity |
1. Modifying of the organic nanoconverters with metal ions in order to design photo-oxidase enzyme mimicking nanomaterial (June, 2021 -> August, 2021).
2. Design and synthesis of photoswitching molecular motor for potential incorporation into DNA fibers (September, 2021 -> December, 2021).
3. Optimization of the photosensitization reaction and nanomachine and nanozymes performance (January, 2022 -> March, 2022).
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| Causes of Carryover |
I changed my job from Saitama University to National Institute of Technology, Gunma College. Therefore, in March 2021 I transferred the chemicals, apparatus and consumables to my new working places. Due to this reason the experiments were stopped in March, 2021 and the incurring budget amount was planed to be used at the next fiscal year.
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