2022 Fiscal Year Final Research Report
Development of solid-phase extractant having water-enriched layer and application of pretreatment for highly water-soluble compounds
| Project/Area Number |
20K05571
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 34020:Analytical chemistry-related
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| Research Institution | Aichi Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 固相抽出 / 親水性高分子 / 水和層 / HILIC / 捕捉特性 |
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| Outline of Final Research Achievements |
A quantitative method for highly water-soluble compounds has been desired in various area. In this research, the fabrication and evaluation of hydrophilic interaction chromatography (HILIC)-type sorbents for solid-phase extraction have been studied for the improvement of adsorption properties of water-soluble compounds.
By optimizing hydrophilic polymer modified onto base resin, which was expected to be important to form water-enriched layer, and base resin itself, HILIC-type sorbents having high adsorption properties of water-soluble compounds were developed. The application method of the developed HILIC-type sorbents was also studied to improve the adsorption properties of water-soluble compounds.
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| Free Research Field |
分析化学
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| Academic Significance and Societal Importance of the Research Achievements |
高い水溶性を有する化合物の定量を可能にすることは、生命科学や環境管理など、幅広い分野に影響を与える技術を提供することにつながる。本研究で開発を進めたHILIC型固相抽出剤は、これまでの前処理技術では定量が困難であった高い水溶性を有する化合物の前処理を可能にするものである。そのため開発したHILIC型固相抽出剤およびそれらの応用展開により、これまでは定量が出来なかった化合物の定量を可能にする可能性があり、その波及効果は大きいものであると考える。
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