2021 Fiscal Year Annual Research Report
Development of sustainable heterogeneous catalysts for step-efficient synthesis of selective oncology drug intermediates.
| Project/Area Number |
20K05576
|
|---|
| Research Institution | Tokyo Metropolitan University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
Siddiki Hakim 北海道大学, 触媒科学研究所, 特任助教 (60722650)
|
|---|
| Project Period (FY) |
2020-04-01 – 2022-03-31
|
| Keywords | Heterogeneous catalysis / Step-efficient Synthesis / Oncology drug |
|---|
| Outline of Annual Research Achievements |
To develop the heterogeneous catalytic methods for the proposed plan, the reactions (1) Dehydrogenative selective methylation and reductive amination of 2-aminobenzamide derivative to quinazolin-4-amine derivative, (2) Dehydrogenative heterocyclization reaction of 1,2-diamino benzene derivative in reaction with methanol produced benzimidazole derivatives, and (3) Hydrolysis of triglycerides to fatty acids are being demonstrated by employing sustainable and environmentally benign green synthesis methods.
For the reactions 1-3 we identified effective catalysts. Further optimization, demonstration, kinetics and mechanistic studies are underway for reactions 1 and 2. For the reaction 3 we have already submitted the paper and it is under review.
|
