2022 Fiscal Year Final Research Report
Boroxazolidone formation as a key reaction for the protein modification
| Project/Area Number |
20K05726
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
Saito Yohei 金沢大学, 先進予防医学研究センター, 助教 (90723825)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | タンパク質化学修飾 / 化学プローブ |
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| Outline of Final Research Achievements |
The handling and temperature control of biomacromolecules such as proteins in an aqueous solution are extremely important to maintain their structure and function. In this study, we developed the conditions for effective formation of boroxazolidone, five membered ring chelate compound constructed from boron and amino acids, in aqueous solution by examining the amino acid side chain and the substituents on boron atom, which could be applied for the chemical modification of biomacromolecules.
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| Free Research Field |
生物分子化学
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| Academic Significance and Societal Importance of the Research Achievements |
ホウ素原子を含む有機化合物はフェニルボロン酸などの一部を除き水溶液中では不安定であり、その多くは水を含まない有機溶媒中での使用に限られていた。本研究では適切な置換基構造を有する分子設計により水溶液中でも利用可能な様々な有機ホウ素化合物を創出し、本構造が生体高分子への化学修飾にも有用であることを明らかにした。今後は本成果を利用して、生命現象の解明や医薬品開発への貢献が期待される。
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