2022 Fiscal Year Final Research Report
Supramolecular complex of peroxiredoxin
| Project/Area Number |
20K05740
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
Nakamura Tsutomu 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ付 (10357668)
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| Co-Investigator(Kenkyū-buntansha) |
氷見山 幹基 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究員 (90828310)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | Peroxiredoxin / 四次構造 / 分子会合 |
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| Outline of Final Research Achievements |
Peroxiredoxin, belonging to a thiol peroxidase group, is widespread in all biological kingdoms. It has many functions such as anti-oxidation, regulation of oxidation stress, chaperoning, depending on higher-order structures and oxidation states. While peroxiredoxins are structurally homologous, their quaternary structures are variant. In this study, we explored the mechanism which determines various quaternary structures of peroxiredoxins.
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| Free Research Field |
タンパク質科学
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| Academic Significance and Societal Importance of the Research Achievements |
相同性の高い三次構造から異なる四次構造を形成可能な事実は、アミノ酸残基の配置に基づく繊細な分子構造の制御により多様かつ機能的な集合体が得られることを示している。従って、集合の形成メカニズム解明と、その制御法を合わせることで、未知の集合様式の形成や集合・解離に対する応答性の付与に繋がり、制御可能な機能性バイオマテリアルの創製が可能となる。
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