Development of therapeutic strategy against congestive heart failure by food ingredients.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K05918
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 38050:Food sciences-related
• Research Institution: Tohoku University
• Principal Investigator: OHSAKI Yusuke 東北大学, 農学研究科, 准教授 (40509212)
• Co-Investigator(Kenkyū-buntansha): 白川 仁 東北大学, 農学研究科, 教授 (40206280)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 食品成分 / 腎障害 / うっ血

Outline of Final Research Achievements

The purpose of this study was to establish strategies for prevention and improvement of congestive heart failure, associated fluid retention, and organ damage by searching for food ingredients that can alleviate renal damage caused by congestion. Unilateral renal congestion model rats were created by occuluding the left renal vein of normal rats with a silver clip. It has been shown that some of the renal injury marker genes induced by blood stasis are significantly reduced when certain food components are administered to this model rat in drinking water or by forced oral administration. Two analogues of this food component were also examined in a similar manner, suggesting that they may at least partially alleviate congestion-induced renal damage. These results indicate that certain food components has a possibility to improve renal injury induced by congestive heart failure.

Free Research Field

栄養生理学

Academic Significance and Societal Importance of the Research Achievements

日本では国民の長寿化に伴う形で心不全患者、中でもうっ血性心不全患者の割合が著しく増加している。うっ血による腎機能の低下は心不全患者の生命予後に大きく影響することから、うっ血に誘導される腎障害改善戦略の構築は非常に重要な課題である。今回我々が探索対象とした食品成分は、一定の摂取経験から有害事象を引き起こす可能性が低いことが証明されており、ヒトへの応用が容易である。
実験に先立ち、うっ血により腎障害が誘導される動物モデル実験系を確立した。この実験系において、腎障害改善効果を有する食品成分をスクリーニングしたところ、複数の候補食品成分が見出された。