2022 Fiscal Year Final Research Report
Elucidation of the control mechanism of GLP-1/incretin signaling by non-nutritional food molecules.
| Project/Area Number |
20K05927
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | GPR120 / GLP-1 / phytosphingosine / teadenol A / isofloridoside / incretin |
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| Outline of Final Research Achievements |
Recently, I found that phytosphingosine (PHS), one of the sphingolipids contained in the plasmamembrane of yeast, is a novel ligand for GPR120 and induces the secretion of GLP-1, one of the incretins. GLP-1 is known to induce anti-diabetes/anti-obesity, and PHS was an interesting molecule that promotes GLP-1 secretion in non-nutritive manner. I believe that such molecules still exist in foods. In this research, I found that teadenol A, contained in microbially fermented tea, and isofloridoside, contained in seaweed, stimulate the secretion of GLP-1 from mouse endocrine cells. Additionally, I also revealed that PHS binds to GPR120 in a region distinct from other ligands.
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| Free Research Field |
食品科学
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| Academic Significance and Societal Importance of the Research Achievements |
インクレチンの一つGLP-1は、インスリンの分泌や食欲の抑制を介して抗メタボリック症候群に働き、２型糖尿病の創薬ターゲットとして注目を集めている。私は本研究でPHS以外にも、teadenol Aとisofloridosideが小腸内分泌細胞からGLP-1の分泌を誘導する事を明らかにした。GLP-1やインクレチンシグナリングは、元来、エネルギーの過剰摂取を防ぐためのフィードバックシステムであるが、私が見出した３つの分子は、何も非栄養的にこのシステムを活性化させる。私の発見は、食品中の非栄養分子の新たな食品機能の存在を示唆しており大変興味深い。
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