2022 Fiscal Year Final Research Report
Prevention of obesity via exercise-induced adipokines by combination of exercise and food-derived factors
| Project/Area Number |
20K05946
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Chubu University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 食品因子 |
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| Outline of Final Research Achievements |
Exercise induces various metabolic changes. However, the role of white adipocytes in the benefits of exercise has not been discussed. Recent study has demonstrated that an exercise-induced adipokine was identified. The purpose of this study was to elucidate the induction of the adipokine by food-derived factors or combination with exercise, and to provide a scientific basis for a new obesity-preventive intervention method. The results showed that an amino acid mixture stimulated secretion of the adipokine. Furthermore, we found that administration of the amino acid mixture increased an endogenous compound. Although administration of the compound did not affect the blood adipokine levels, we found that it induced beige adipocytes formation and elucidated its mechanism of action.
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| Free Research Field |
食品科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から食品由来因子の摂取で運動しなくても対象アディポカインの分泌が刺激されることが明らかになったこと、運動と食品由来因子の併用が内因性物質濃度を高め、このことが褐色脂肪細胞を誘導すること、以上の2つの知見から学術的に新たな経路や機構が提唱できる。これらの成果を基盤としてサプリメントなどの新しい食品の創製への貢献や新たな食事と運動メニューの提案などの社会的意義を見出している。
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