2022 Fiscal Year Final Research Report
Studies of feline morbillivirus pathogenesis
| Project/Area Number |
20K06389
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 42020:Veterinary medical science-related
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
Furuya Tetsuya 東京農工大学, (連合)農学研究科(研究院), 教授 (60647676)
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| Co-Investigator(Kenkyū-buntansha) |
田中 良和 日本獣医生命科学大学, 獣医学部, 教授 (50291159)
中尾 洋一 早稲田大学, 理工学術院, 教授 (60282696)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 猫モルビリウイルス / 病原性 / 抗体検査 / 腎臓病 / 予防 |
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| Outline of Final Research Achievements |
In this study, using feline kidney tissue sections, immunostaining with an anti-FeMV antibody and TUNEL assay to detect apoptotic cells were performed. Apoptosis was involved in the mechanism of FeMV's pathogenesis. Antiviral activity against feline coronavirus was discovered in the Chinese herbal medicine library, and currently, we are planning to conduct research using FeMV-infected cats in collaboration with Thailand regarding its effect on FeMV. Recombinant N proteins of FeMV and canine distemper virus were produced and used to detect sero-cross reactivity between the N proteins, and some cat plasma samples contained antibody that react both FeMV and CDV N proteins, suggesting need of attention to such cross reactivity upon antibody test for FeMV infection.
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| Free Research Field |
感染症学
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| Academic Significance and Societal Importance of the Research Achievements |
本課題は、猫の慢性的な腎臓病の可能性を増加させる猫モルビリウイルス（FeMV）感染症について、その病原性と予防や治療の可能性を研究するものである。今回、FeMV感染腎臓組織において、アポトーシス細胞が増加していることが明らかになり、FeMVの腎臓病への関与がより明らかになった。漢方薬ライブラリーから発見された抗ウイルス作用を持つ漢方植物抽出薬を始め、今後は、FeMVに対する治療と予防効果について、より研究を進めて行く予定である。
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