CFTR gene polymorphism in hepatobiliary pancreatic diseases of dogs

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K06433
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42020:Veterinary medical science-related
• Research Institution: Yamaguchi University
• Principal Investigator: Baba Kenji 山口大学, 共同獣医学部, 准教授 (90452367)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: CFTR / 遺伝子多型 / 肝胆膵 / 胆嚢粘液嚢腫 / 犬

Outline of Final Research Achievements

In this study, five single nucleotide polymorphisms (SNPs) of CFTR gene were identified in dogs with hepatobiliary pancreatic diseases. One of them was significantly related to accumulation of biliary sludge and gallbladder mucocele. The SNP caused a decrease in the ion channel activity of CFTR in cultured cells. SNPs of CFTR gene may be related to the pathogenesis of gallbladder mucocele in dogs.

Free Research Field

臨床獣医学

Academic Significance and Societal Importance of the Research Achievements

本研究では，陰イオンチャネルであるCFTRの機能低下が犬の胆嚢粘液嚢腫の病態に関与することが示唆された。この結果は，本疾患の病態解明および新規治療法の開発に大いに貢献するものと考えられる。