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2022 Fiscal Year Final Research Report

Role of CREG1 on the regulation of thermogenic cells and body temperature

Research Project

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Project/Area Number 20K06450
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 42030:Animal life science-related
Research InstitutionChubu University

Principal Investigator

YAMASHITA Hitoshi  中部大学, 生命健康科学部, 教授 (20342967)

Co-Investigator(Kenkyū-buntansha) 後藤 亜由美  中部大学, 生命健康科学部, 助手 (20780969)
竹内 環  中部大学, 生命健康科学部, 講師 (90392018)
Project Period (FY) 2020-04-01 – 2023-03-31
KeywordsCREG1
Outline of Final Research Achievements

Brown fat and skeletal muscle, the major thermogenic organs, play critical roles for regulation of body temperature and energy metabolism. We previously discovered cellular repressor of E1A-stimulated genes 1 (CREG1) as a novel endocrine factor that stimulates brown fat formation and prevents diet-induced obesity in mice. Here we report that CREG1 also stimulates AMPK activation and glucose uptake via IGF2 receptor, contributing to regeneration in skeletal muscle. Compared to CREG1-Tg mice, CREG1-Tg/UCP1-KO mice develop obesity under the conditions of high-fat diet and thermoneutrality, indicating that UCP1 thermogenesis is indispensable to the inhibitory effect of CREG1 against diet-induced obesity. CREG1 would be a target molecule to improve the function of the thermogenic organs and age-related metabolic disability.

Free Research Field

分子細胞生物学

Academic Significance and Societal Importance of the Research Achievements

褐色脂肪と骨格筋による熱産生は、ヒトを含む恒温動物の体温調節とエネルギー代謝において必須の生理機能であり、その衰えは肥満やメタボ、あるいは筋萎縮(サルコペニア)の原因となり老化を加速する。本研究は内分泌因子CREG1がこれらの主要な熱産生組織の分化や機能に重要な役割を果たし、加齢性代謝疾患の予防・改善のための標的分子となることを初めて明らかにしたものであり、体温調節/エネルギー代謝の分子調節機構に関する理解と研究分野の発展に資するものと思われる。また、超高齢社会における健康長寿をめざす我が国において社会的意義の高いものと考える。

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Published: 2024-01-30  

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