Study on the mechanism of sperm and embryo transport in oviduct in situ

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K06468
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 42040:Laboratory animal science-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: Toshiaki Hino 旭川医科大学, 医学部, 准教授 (10550676)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 卵管 / 配偶子 / 受精卵 / 輸送

Outline of Final Research Achievements

In this study, we examined the transport of zygotes and embryos through the oviduct in situ. We observed that oocytes moved toward the site of fertilization against the fluid flow directed towards the ovary, driven by ciliary movement. Additionally, we found that embryos were propelled towards the uterus due to the peristaltic movement of the oviduct and the resulting fluid flow.

Free Research Field

生殖生物学

Academic Significance and Societal Importance of the Research Achievements

ヒトや家畜において、不受精による受胎率低下や原因不明の不妊が報告されている。これらの異常を理解し、その原因を解明するためには、配偶子がどのように卵管内を移動して受精し、初期胚がどのようにして子宮にいたるのかについての正確な理解が求められる。本研究成果は、体内受精から妊娠に至るまでのメカニズム解明のみならず、ヒトの不妊症や家畜の受胎率低下の原因解明に繋がると期待される。