2023 Fiscal Year Annual Research Report
The Effect of Active Zone Protein Dynamics on Synaptic Vesicle Release Probability
| Project/Area Number |
20K06593
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
DeSchutter Erik 沖縄科学技術大学院大学, 計算脳科学ユニット, 教授 (00466319)
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| Co-Investigator(Kenkyū-buntansha) |
HEPBURN Iain 沖縄科学技術大学院大学, 計算脳科学ユニット, 客員研究員 (20604200)
GALLIMORE Andrew 沖縄科学技術大学院大学, 計算脳科学ユニット, 客員研究員 (50838422)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | Synapse / Plasticity / Hippocampus / Computational biology / Systems biology |
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| Outline of Annual Research Achievements |
After extensive testing, validation and with the addition of error-reporting, we released STEPS 5.0 in March 2023 as the first public release of STEPS to include all of the vesicle-modelling tools developed within this project.
A manuscript that describes all of these features has been accepted by Communications Biology under the Nature portfolio and is awaiting publication.
From the computational modelling side, we recently supplemented this work with an experimental study in isolated hippocampal neuron cultures by collaborators that confirms predictions of the model about how the degree of vesicle usage depends on firing frequency. We have now finalised this study and are under the process of submission to a major journal.
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