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2023 Fiscal Year Annual Research Report

The Effect of Active Zone Protein Dynamics on Synaptic Vesicle Release Probability

Research Project

Project/Area Number 20K06593
Research InstitutionOkinawa Institute of Science and Technology Graduate University

Principal Investigator

DeSchutter Erik  沖縄科学技術大学院大学, 計算脳科学ユニット, 教授 (00466319)

Co-Investigator(Kenkyū-buntansha) HEPBURN Iain  沖縄科学技術大学院大学, 計算脳科学ユニット, 客員研究員 (20604200)
GALLIMORE Andrew  沖縄科学技術大学院大学, 計算脳科学ユニット, 客員研究員 (50838422)
Project Period (FY) 2020-04-01 – 2024-03-31
KeywordsSynapse / Plasticity / Hippocampus / Computational biology / Systems biology
Outline of Annual Research Achievements

After extensive testing, validation and with the addition of error-reporting, we released STEPS 5.0 in March 2023 as the first public release of STEPS to include all of the vesicle-modelling tools developed within this project.
A manuscript that describes all of these features has been accepted by Communications Biology under the Nature portfolio and is awaiting publication.
From the computational modelling side, we recently supplemented this work with an experimental study in isolated hippocampal neuron cultures by collaborators that confirms predictions of the model about how the degree of vesicle usage depends on firing frequency. We have now finalised this study and are under the process of submission to a major journal.

  • Research Products

    (2 results)

All 2024 2023

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 1 results,  Open Access: 2 results)

  • [Journal Article] Vesicle and reaction-diffusion hybrid modeling with STEPS2024

    • Author(s)
      Hepburn Iain, Lallouette Jules, Chen Weiliang, Gallimore Andrew R., Nagasawa-Soeda Sarah, De Schutter Erik
    • Journal Title

      Communications Biology

      Volume: - Pages: in press

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamic Regulation of Vesicle Pools in a Detailed Spatial Model of the Complete Synaptic Vesicle Cycle2023

    • Author(s)
      Gallimore Andrew R.、Hepburn Iain、Rizzoli Silvio、De Schutter Erik
    • Journal Title

      bioRxiv

      Volume: - Pages: 551909

    • DOI

      10.1101/2023.08.03.551909

    • Open Access / Int'l Joint Research

URL: 

Published: 2024-12-25  

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