The new aspects of lysosomal signal regulation by Ragulator

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K06623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 44010:Cell biology-related
• Research Institution: Osaka University
• Principal Investigator: Nada Shigeyuki 大阪大学, 微生物病研究所, 准教授 (50291448)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: mTORC1 / Ragulator / Lamtor1 / p18

Outline of Final Research Achievements

Ragulator is an important component for mTORC1 regulation. In this study the physiological function of Ragulator in intestinal epithelium was evaluated by use of conditional knockout mice. The results showed that Ragulator is essential for the development of intestinal epithelium, especially for goblet cell function. In addition, knockout cell studies revealed that the structure of Ragulator is indispensable for amino-acid regulation of mTORC1 activation.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

この研究はｍTORC1活性調節の中でもRagulatorに関する部分に焦点を当てたものである。mTORC1研究は国内外に多数あるが、Ragulatorに関しては我々が同定し機能を明らかにしてきた。当研究もその一翼を担うものであり、mTORC1の調節と機能に関する新たな知見を提供できたものと考える。