2022 Fiscal Year Final Research Report
Mechanisms of cortical formation mediated by neuronal repulsive signals
Project/Area Number |
20K06670
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 44020:Developmental biology-related
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Research Institution | Keio University |
Principal Investigator |
HIROTA Yuki 慶應義塾大学, 医学部(信濃町), 講師 (00453548)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Keywords | 大脳皮質 / 神経細胞移動 / リーリンシグナル / ニューロン反発因子 |
Outline of Final Research Achievements |
Accurate neuronal positioning is essential for proper functioning of the neural network. The cessation of neuronal migration during cortical formation is an important step that contributes to the characteristic pattern of layer formation. In this study, we focused on the abundant expression of the Reelin receptor VLDLR in neurons at the time of migration termination during cortical formation and found that Reelin signaling is required for neuronal migration arrest. Furthermore, we found that cell adhesion molecules are localized to neurites by the action of neural repulsive factor and Reelin signaling in neurons at the time of migration arrest, leading to the discovery of a signal that has an important function in the process of migration arrest.
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Free Research Field |
発生生物学
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Academic Significance and Societal Importance of the Research Achievements |
大脳皮質形成において、神経細胞移動停止は後続の神経細胞を最表層に送り込むことによって層形成パターンを完成させる重要なプロセスであり、本研究ではこのプロセスにおけるリーリンシグナルと神経反発因子による協調的な制御機構を明らかにした。また、大脳皮質層構造に異常が生じると統合失調症や自閉症スペクトラム障害等の精神神経疾患の発症リスクが高まることが知られていることから、本研究で得られた成果は将来的にはこれらの疾患の病態解明にも寄与できるものである。
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