2023 Fiscal Year Final Research Report
Changes in synaptic connections supporting memory consolidation and their regulatory mechanisms
| Project/Area Number |
20K06860
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Osaka Metropolitan University (2022-2023)
Osaka City University (2020-2021) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 記憶 / 大規模電気生理学 / 睡眠 |
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| Outline of Final Research Achievements |
Memory is acquired through experiences during wakefulness and consolidated during subsequent sleep phases. It has been suggested that a cross-regional brain network undergoes changes throughout this memory formation process, but the details have remained unclear. In this study, we continuously recorded the activity of numerous neurons at a single-cell resolution in three brain regions of freely behaving rats, from the acquisition of memory to the initial stages of its consolidation. We revealed that synchronized activity across brain regions emerged after memory acquisition. Furthermore, we found that such synchronized activity coincides with fast network oscillations, which are presumably related to plastic changes of synaptic connections.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、記憶の定着と脳領域横断的な同期活動が関連しており、これらの同期活動は脳波の速いオシレーションをともなって現れることが明らかになった。これまでの研究により、脳波の速いオシレーションはシナプス結合の可塑的な変化との関連が指摘されている。このことは、脳領域横断的な同期活動が領域横断的な神経回路というマクロの構造と、シナプス結合というミクロの変化をつなぐ現象であることを示唆しており、学術的に大きな意味がある。また、このような記憶メカニズムの基礎過程の解明は、認知症をはじめとするさまざまな記憶機能障害の病態理解と治療原理の発見にも寄与すると期待される。
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