2023 Fiscal Year Annual Research Report
The nature and roles of cellular metabolism and energy in the regulation of neuronal chain migration
| Project/Area Number |
20K06865
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
ZHU YAN 国立遺伝学研究所, 遺伝形質研究系, 助教 (50464235)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | chain migration / precerebellar neurons / OXPHOS / tangential / radial / adhesion / protease |
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| Outline of Annual Research Achievements |
Our objective is to understand characteristics of chain migrating neurons, in particular its energy expenditure and metabolic sources. We generated a knockout mice line deficient in a transcription factor known to promote OXPHOS pathway and found that the chain migrating precerebellar neurons showed defect in switching from tangential to radial migration. In a separate approach, we have found that fine-tuning the level of a key adhesion molecule, possibly by a protease system, also contribute to this process.
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