Roles of NG2 glia in maintenance of mitochondrial integrity in neurons

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K06883
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Osaka Ohtani University (2023); Institute of Physical and Chemical Research (2020-2022)
• Principal Investigator: YASUHISA TAMURA 大阪大谷大学, 薬学部, 教授 (60446523)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: ミトコンドリア / ニューロン / NG2グリア / 細胞膜融合

Outline of Final Research Achievements

Recently, mitochondrial dysfunction in neurons is related with pathogenesis of neurodegenerative diseases. The maintenance of mitochondrial integrity in neurons is important to preserve neuronal function. This study investigated whether NG2 glia is concerned with maintaining of mitochondrial function in neurons. We showed that NG2 glia is related with maintenance of mitochondrial integrity in neurons via mitochondrial transfer through membrane fusion.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究では、NG2グリアが細胞膜融合を介したミトコンドリア供給により神経細胞でのミトコンドリア品質維持に関わるという成体脳での新たな役割を見出すことに成功した。これらの成果は、神経変性疾患の病態解明や新たな治療法開発の一助となりうる情報を提供するものであると考える。