2022 Fiscal Year Final Research Report
Investigating the Promoter Motifs Which are Capable of Distinguishing the Specific Cell Types in Macaque Visual Cortex.
| Project/Area Number |
20K06898
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 46020:Anatomy and histopathology of nervous system-related
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| Research Institution | Kyoto University (2021-2022)
Tamagawa University (2020) |
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Principal Investigator |
Saito Harumi 京都大学, 高等研究院, 特定助教 (20311342)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | visual cortex / blind spot / cell type specific / feed back |
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| Outline of Final Research Achievements |
To identify cell type-specific promoters in macaque V1, I have made Layer specific Cage library and compared the results with the prefrontal cortex (PFC). I found the differences in gene expression between V1 and PFC, however,I could not perform further experiments to define the specific genes for the targeting because of COVID-19.
I have analyzed the information processing of perceptual filling-in in V1 blind spot region of macaque brain. Perceptual filling-in is responsible for the completion of missing information across the visual field such as blind spot (BS) and scotoma. Some features of response profiles in BS region in macaque V1 suggested the possible involvement of feedback from higher visual cortical area. For purpose of understanding the neural processes of top-down mechanisms involved in perceptual filling-in, we analyzed the dynamics of layer specific neural activities within and outside of V1 BS region by LFP and unit recordings using liner array electrode.
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| Free Research Field |
Neuroscience
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| Academic Significance and Societal Importance of the Research Achievements |
我々の充填知覚の実験結果から、Ｖ１よりも高次の視覚野からのフィードバックのいわゆる予測信号によって盲点周辺の視覚情報がＶ１の盲点領域内に流入することが充填知覚が起こることが分かった。また更に、フィードバックによって送られてくる輪郭と面の情報は、盲点領域内において異なる細胞種が受け取っていることが分かった。この結果は、充填現象を理解する為の重要な知見であると共に、霊長類の視覚認知において、大脳皮質内でフィードバックの機能的意義、および情報処理機構がどの様に行われているのか、その理解を深める為に役立つ。
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