A role of insula neural circuits in aversive behavior

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K06928
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 46030:Function of nervous system-related
• Research Institution: Kumamoto University
• Principal Investigator: Takemoto Makoto 熊本大学, 大学院生命科学研究部(医), 講師 (20543408)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 島皮質

Outline of Final Research Achievements

The insular cortex (insula) plays a role in taste sensation and feeding behavior, yet how insular neurons act remains unclear. We investigated the neuroanatomy of mouse insula layer 5 (L5) projecting to subcortical structures in detail, and found two sublayers (i.e. L5a and L5b) with distinct subcortical projections. Additionally, by using an optogenetic technique, we demonstrated that the activation of L5a and L5b suppressed and facilitated water drinking behavior, respectively, in thirsty mice. This finding suggests a role for insula in a top-down modulation of appetitive behaviors, and provides an insight into the therapeutic approach to feeding disorders (e.g. binge-eating and anorexia) and addiction.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究は、動機付け行動のトップダウン調節機構の一端を明らかにしたものであり、摂食障害（過食症・拒食症）や依存症等の治療法開発に重要な示唆を与える。