Development of an environmentally benign direct mass production system using sunlight

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K06942
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
• Research Institution: Gifu Pharmaceutical University
• Principal Investigator: Itoh Akichika 岐阜薬科大学, 薬学部, 教授 (10203126)
• Co-Investigator(Kenkyū-buntansha): 山口 英士 岐阜薬科大学, 薬学部, 講師 (10737993) ; 多田 教浩 岐阜薬科大学, 薬学部, 講師 (20468234)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 太陽光 / 環境負荷低減 / 光反応

Outline of Final Research Achievements

A prototype reaction system was constructed. The whole system consists of two devices, a device for efficiently concentrating sunlight and a photoreactive flow microreactor. We connected the two with an optical fiber and conducted verification of introducing the collected sunlight into the flow reactor, and confirmed that sunlight could be introduced stably for a long period of time. Therefore, using this device, the synthesis of ibuprofen by the photo-Favorskii reaction and the HAT reaction were verified. As a result, in any reaction, a significant improvement in yield could be achieved as compared with the batch reaction using an ordinary flask.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

よりクリーンなエネルギー源である太陽光を用いた物質変換デバイスの設計・開発検討を行い、上記の様な装置を構築、さらにそれを用いて通常のバッチ反応では反応速度が遅い反応に関して、反応効率の向上を検討した。その結果、イブプロフェン合成における光Favorskii反応とHAT反応に関して反応効率の大幅な向上を達成することに成功した。今後本装置をさらに改良することにより、人工灯であるLEDに匹敵する物質変換デバイスの開発が期待される。