Development of NIR-absorbing dye and molecular functions for the photochemical treatment of lysosome disease

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K06978
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
• Research Institution: Aichi Gakuin University
• Principal Investigator: Kamino Shinichiro 愛知学院大学, 薬学部, 教授 (20537237)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 近赤外光 / キサンテン / ライソゾーム病

Outline of Final Research Achievements

We have been working on the development of Near-Infrared (NIR)-absorbing organic dyes for the application to phototherapy of lysosome disease. Through this project, we have succeeded in obtaining the two new results as shown below. [1] Synthesis of Polymethine-embedded Rhodamine and development of molecular function. [2] Synthesis of Bridged Xanthene and development of molecular function

Free Research Field

物理有機化学、光化学

Academic Significance and Societal Importance of the Research Achievements

NIRを利活用できる有機色素の創製の分子機能の開発は、診断と効果的な治療を同時に遂行するセラノスティクス薬剤の創薬を発展させる上で学術的意義を有する。また近赤外分子技術を発展させていくことはライソゾーム病、代謝異常症やパーキンソン病など、生体代謝物が蓄積することで全身症状が現れる疾患の光化学治療薬・治療法へ応用可能であり，希少・難治性疾患研究の発展に貢献できる。