2022 Fiscal Year Final Research Report
Development of albumin-coated stealth nanoparticles for effective anticancer therapy
| Project/Area Number |
20K06995
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
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| Research Institution | Sojo University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | ドラッグデリバリーシステム / アルブミン / ナノ粒子 / 抗がん剤治療 |
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| Outline of Final Research Achievements |
This study was carried out to investigate the effects of the differences in the surface coverage of nanoparticles with albumin on the avoidance of capture by the reticuloendothelial system (RES) and the antitumor effect. The results showed that nanoparticles with high albumin coverage could avoid capture by the RES, and this stealth effect improved the accumulation of nanoparticles in cancer tissues and the anticancer effect. Thus, it was suggested that the nanoparticles covered with albumin could provide effective and safe anticancer drug therapy.
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| Free Research Field |
薬物動態学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究でナノ粒子のステルス化に必要なアルブミンによる被覆条件が明確になったことから、このナノ粒子を用いた効果的かつ安全な抗がん剤治療が可能になると考えられる。また、アルブミンによる被覆は、今回検討したナノ粒子以外にも、リポソームや高分子ミセル等、他のナノ粒子への応用も期待できる。さらに、本ナノ粒子に蛍光物質、光増感剤や磁性物質などを封入することで、薬物治療のみならず、がん病巣のイメージング、光線力学療法や温熱療法等にも応用でき、がんの治療・診断の幅を格段に広げることができると考えられる。
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