Identification of novel TYK2 functions involved in the regulation of autoimmune disease pathogenesis

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K07010
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: Hokkaido University
• Principal Investigator: Muromoto Ryuta 北海道大学, 薬学研究院, 准教授 (30455597)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: TYK2 / 炎症 / サイトカイン

Outline of Final Research Achievements

We focused on the possibility that TYK2, a JAK family kinase responsible for cytokine signaling, may have a kinase-independent role in increasing the risk of developing some immune diseases. In this study, we identified candidate novel effector proteins whose expression is regulated by TYK2 and affects macrophage function. We also found that TYK2 may suppress nuclear receptor function in a kinase-independent manner and that this function is enhanced by a TYK2 SNP variant.

Free Research Field

生物系薬学

Academic Significance and Societal Importance of the Research Achievements

TYK2機能と免疫・炎症疾患との新たなつながりが示唆された。TYK2が既知の役割であるJAK-STATシグナル伝達とは独立に免疫・炎症反応促進に影響をもつことが示唆され、この解析を継続しさらに詳細を解明することで、TYK2を標的としキナーゼ活性阻害とは異なる作用機序の新規自己免疫疾患治療法を考案する基礎となりうると考えられた。