2022 Fiscal Year Final Research Report
Exploration of Novel Anti-Methylmercury Agents Using Oleanoic Acid Saponin Derivatives Library
| Project/Area Number |
20K07108
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | メチル水銀 / 抗メチル水銀化合物 / オレアノール酸サポニン誘導体 |
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| Outline of Final Research Achievements |
We investigated the protective effect of oleanolic acid-3-glucoside (OA3Glu), a candidate compound for anti-MeHg drugs, against MeHg toxicity, and found that OA3Glu was effective in reducing MeHg-induced neurotransmission and motor disorders. We also searched for compounds with higher anti-MeHg activity using a library of oleanolic acid saponin derivatives and investigated the difference in anti-MeHg activity depending on the type of monosaccharide attached to the C3 position of oleanolic acid. The results showed that oleanoic acid-3-galactoside, which has galactose attached to the C3 position, exhibited the same level of anti-MeHg activity as OA3Glu in vitro.
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| Free Research Field |
毒性学
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| Academic Significance and Societal Importance of the Research Achievements |
我々は食餌を介して微量ながらも絶えずMeHgにばく露し続けている。本研究で見出したオレアノール酸-3-グルコシドはMeHgによる神経伝達障害を軽減する作用があると考えられた。日常的に魚介類の摂食等によりばく露されるMeHgに対する予防薬・治療薬は現在までに見られないが、OA3GluはこのようなMeHgばく露に対して有効な高MeHg薬となりうると考えられる。
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