2023 Fiscal Year Final Research Report
Exploratory research on prenyl derivatives with anti-glycation and anti-periodontopathogenic activity to prevent and ameliorate periodontal disease-related conditions.
| Project/Area Number |
20K07122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中尾 龍馬 国立感染症研究所, 細菌第一部, 主任研究官 (10370959)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Keywords | 歯周病 / 糖化 / Porphyromonas gingivalis / CMA / プレニル誘導体 / ポリフェノール / コラーゲン / AGEs |
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| Outline of Final Research Achievements |
In this study, we searched for natural compounds that inhibit the growth of the periodontal pathogen Porphyromonas gingivalis (Pg) using materials that can be consumed daily and found petroselinic acid from Foeniculum vulgare, mahanimbine from curry leaves, and Epigallocatechin-3-O-gallate from matcha tea as active compounds. We also focused on CMA (Nε-(carboxymethyl) arginine), an advanced glycation end-product that accumulates explicitly in collagen, which is abundant in the oral environment and searched for natural compounds that inhibit the formation of CMA. Xanthohumol D from hops and (-)-catechin from Ampelopsis glandulosa var. heterophylla were found as active compounds.
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| Free Research Field |
天然物化学
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| Academic Significance and Societal Importance of the Research Achievements |
歯周病は口腔のみならず、糖尿病や動脈硬化症などの全身疾患の誘因となることが近年明らかとなり、社会的にも公衆衛生学的にも歯周病対策の重要性は高まっている。とりわけ、薬剤耐性菌の問題が深刻化している現在、抗菌薬に頼らない方法、たとえば抗菌活性を有する食品を応用した歯周病制御法の確立が求められている。本研究により、食品由来エキスと化合物の強力なPgの増殖抑制活性と作用機序の詳細を明らかすることができた。また、抗糖化（CMA生成抑制）化合物の活性に必須のコア構造を新たに示すこともできた。これらの知見より、歯周病と歯周病関連の全身疾患を予防・改善できる食品素材候補を見つける手立てが明らかとなった。
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