Search and development of drugs for prevention and treatment of subarachnoid hemorrhage complications from natural products.

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K07123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47050:Environmental and natural pharmaceutical resources-related
• Research Institution: Microbial Chemistry Research Foundation
• Principal Investigator: Wada Shun-ichi 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員 (40450233)
• Co-Investigator(Kenkyū-buntansha): 奈良岡 征都 弘前大学, 医学部附属病院, 講師 (10455751)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: くも膜下出血 / トレハロサミン / trehalosamine / トレハロース / trehalose / 抗酸化物質 / 食品植物 / 微生物

Outline of Final Research Achievements

The substances that could be used as therapeutic agents for subarachnoid hemorrhage (SAH) were searched and evaluated. Trehalose and three analogs showed a tendency to increase the survival rate of brain neurons and suppress inflammation in a rat SAH model. One analog was about 500 times more effective than other compounds, and it is expected that this analog will lead to the development of therapeutic drugs in the future. In addition, natural antioxidants that are promising as new therapeutic agents for SAH were searched in this research. Twenty-three compounds, many of which have been poorly studied, were purified and identified, and five of these were new compounds. Considering the recent difficulty in discovering new compounds in the field of natural product chemistry, this result can be regarded to be highly efficient.

Free Research Field

天然物利用

Academic Significance and Societal Importance of the Research Achievements

くも膜下出血は、投薬により合併症を抑制することで予後が改善できるものと考えられるが、過去20年以上、新たな治療薬の開発はほとんど進んでいない。本研究で注目されたtrehalose類縁体や、新たに発見された抗酸化物質をもとに開発される治療薬が死者や社会復帰困難な患者を減らせるようであれば、社会への貢献が大きいものと期待される。また、本研究で注目した有効化合物の作用機構について理解を深めることで、脳血管障害や関連疾患の病態や治療における基礎的かつ全般的な分子機構の把握に役立つものと期待される。さらに本研究は、天然物化学分野における新規化合物探索法にも新たに効率的な一例を加えたものと言える。