2022 Fiscal Year Final Research Report
Effects of platinum-containing drugs on tissue and cellular distribution of trace metal-relaterd proteins
| Project/Area Number |
20K07143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Osaka Medical and Pharmaceutical University (2021-2022)
Osaka University of Pharmaceutical Sciences (2020) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | プラチナ / 癌 |
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| Outline of Final Research Achievements |
Limited quantities of clinical samples are available. As a pretreatment for efficient measurement of metal elements, the conditions for ashing using a microwave sample digester were investigated, and the treatment conditions were optimized. After platinum-based chemotherapy, it is detected in the body for a long period of time, and it was suggested that its elimination from the blood is related to factors such as albumin, regardless of renal function. In addition to the variation of essential trace metals in the body, the isotope effect was also examined for the same patient samples, and it was found that the isotopic ratios of iron, copper, and zinc in the plasma may differ from the natural ratios. Further studies are required.
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| Free Research Field |
臨床薬学
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| Academic Significance and Societal Importance of the Research Achievements |
プラチナ系抗癌剤は消化器癌などの固形癌に対して汎用される薬剤である。一方で、プラチナが金属であることから同薬剤を用いる治療によって鉄、銅、亜鉛といった生体に必須の微量金属元素（バイオメタル）に影響する可能性がある。バイオメタルの変動をモニターすることによって生体が受けた影響を定量的に評価できる可能性があり、疾患の診断や治療効果の判定ならびに副作用の発現予測に応用できると考えている。
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