Development of spray formulation that enable non-invasive transdermal delivery of nucleic acid with non-lamellar liquid crystal.

2022 Fiscal Year Final Research Report

• Project/Area Number: 20K07204
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 47060:Clinical pharmacy-related
• Research Institution: Josai University
• Principal Investigator: Todo Hiroaki 城西大学, 薬学部, 准教授 (10383184)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Keywords: 経皮送達 / 核酸 / 脂質 / 非ラメラ液晶

Outline of Final Research Achievements

Non-lamellar liquid crystal-forming lipids are attracting attention as next-generation skin permeation enhancers because they act on the intercellular lipid structure that responsible for the skin barrier function. Currently, the development of medium- and high-molecular drugs is remarkable, and many attempts have been conducted to absorb them by parenteral means. In this application study, an aerosol formation with non-lamellar liquid crystal forming lipid containing decoy oligonucleotide NF-κB, which has an attracting attention as a treatment for atopic dermatitis, was prepared. As a result, it was suggested that the prepared topical aerosol formulation can transdermally deliver an amount of nucleic acid drug that can be expected to be therapeutically effective.

Free Research Field

薬剤学、薬物送達学

Academic Significance and Societal Importance of the Research Achievements

非侵襲的に核酸を送達できる手法の開発は、生活の質の改善に大きく貢献できることから、強く望まれている。本手法は、これまで困難であった中分子量の薬物を送達できることから、学樹的にも社会的にも大きな意義があると考えている。