2022 Fiscal Year Final Research Report
Realization of precision medicine by constructing platform of dry powder inhaler formulation
| Project/Area Number |
20K07212
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Osaka Medical and Pharmaceutical University (2021-2022)
Osaka University of Pharmaceutical Sciences (2020) |
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Principal Investigator |
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Keywords | 数値シミュレーション / 機能性素材 / 吸入粉末剤 / 粒子設計 / 噴霧乾燥法 / 水溶性多糖類 / 金属有機構造体 / シクロデキストリン |
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| Outline of Final Research Achievements |
In this study, the composite particles between drugs and biocompatible excipients were prepared by spray-drying to have better advantages to carrier techniques. Specifically, sugars have advantages like cheap in cost and have low probability to trigger toxicity in the human body. Their building blocks are usually monosaccharides which have excellent biocompatibility. We succeeded in preparing composite particles with low density and large surface areas. Also, we succeeded in preparing particles of polysaccharides with desired aerodynamic diameters via spray-freeze drying. In addition, the differences in pulmonary morphology and particle behavior among patients were compared using in silico simulations.
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| Free Research Field |
物理薬剤学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で、生体適合性が高い多糖類により様々な空気力学的粒子径を有する粒子を設計することに成功した。この技術は、低分子医薬品の吸入粉末剤だけでなく、中分子や抗体医薬といった様々なモダリティへの応用も期待できる点で非常に重要である。また、in silico技術によって確認した患者毎の肺の違いやその中での粒子挙動については、これまでin vitroでの評価しかなかった吸入粉末剤について、新たな適正評価に関する可能性が期待できる。また、AI技術の発達に伴い、肺モデルの作製をより潤滑にして、肺内部での粒子挙動について把握できれば、患者の特性に応じた粒子設計情報を得ることも可能となる。
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