Spaciotemporal analysis for developing inferior vena cava

2023 Fiscal Year Final Research Report

• Project/Area Number: 20K07229
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 48010:Anatomy-related
• Research Institution: Gifu Pharmaceutical University (2023); Iwate Medical University (2020-2022)
• Principal Investigator: Murashima Aki 岐阜薬科大学, 薬学部, 講師 (50637105)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Keywords: 還流路形成 / 遺伝子改変マウス

Outline of Final Research Achievements

Although the development of the inferior vena cava (IVC) is based on changes in the cardinal veins (posterior-, sub-, supra), there has been no three-dimensional analysis that incorporates the development of the surrounding tissues. In this study, we used advanced imaging techniques and genetically engineered mice to reevaluate the development of the IVC. The results suggested that a novel venous structures might contribute to the IVC. This study indicates a new developmental origin of the IVC in mammals providing new concepts not only in embryology but also in comparative anatomy.

Free Research Field

解剖学

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、一世紀以上議論が続いている哺乳類における下大静脈の発生メカニズムを比較解剖学および発生学の両方の視点から発展させ、新たな発生起源を明らかにした点にある。最新のイメージング技術と遺伝子改変マウスを用いた解析により、従来見逃されていた静脈構造の形成メカニズムを解明し、体幹還流路の理解を深化させた。本研究は血管形成異常に関連する疾患の診断や治療法の開発に寄与する可能性があり、社会的にも意義がある。